中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
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《生命科学》 2010, 22(10): 1069-1073
SDF-1/CXCR4轴在骨再生修复中的研究进展
廖新根1,殷 明2,李士勇3*,吴梨华1,刘 哲1,付明福1
(1南昌大学研究生院医学部,南昌330006;2南昌大学第二附属医院骨科,南昌330006;3 南昌大学第二附属医院分子医学中心,南昌330006)

摘 要:基质细胞衍生因子-1(stromal cell-derived factor-1, SDF-1)及其受体CXCR4构成SDF-1/CXCR4轴系统具有许多重要的生物学特性和功能。近年来随着该领域的研究不断深入,越来越多的发现表明,SDF-1/CXCR4轴系统在组织损伤及修复中起着重要作用,其在骨组织再生修复中的作用也日益受到关注。该文主要对SDF-1/CXCR4轴系统的生物学特性及其在骨再生修复中的作用进行综述。
关键词:基质细胞衍生因子-1;SDF-1/CXCR4轴系统;生物学特性;骨再生修复
中图分类号:Q813;R683  文献标识码:A


    


 

 
Progress of SDF-1/CXCR4 axis in bone regeneration
LIAO Xin-gen1, YIN Ming2, LI Shi-yong3*, WU Li-hua1, LIU Zhe1, FU Ming-fu1
(1 Graduate School of Medicine, Nanchang University, Nanchang 330006, China; 2 Second Affiliated Hospital of Nanchang University, Nanchang 330006, China; 3 Center for Molecular Medicine, Second Affiliated Hospital of Nanchang University, Nanchang 330

Abstract: The SDF-1/CXCR4 axis system constituted by stromal cell-derived factor -1 (SDF-1) and its receptor CXCR4 has many important biological characteristics and functions. With deepening research in the field in recent years, the growing number of findings suggest that the SDF-1/CXCR4 axis system plays an important role in regeneration and repair of tissue injury , what{$39}s more, the role of SDF-1/CXCR4 axis system in the regeneration of bone tissue are also increasingly concerned. This article reviews the biological characteristics of the SDF-1/CXCR4 axis system and its role in bone regeneration and repair.
Key words: stromal cell-derived factor-1; SDF-1/CXCR4 axis system; biological characteristics; bone regeneration and repair

 
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