中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(10): 1005-1108
端粒酶线粒体转位
文 蕾,凌贤龙*
(第三军医大学新桥医院消化科,重庆 400038)

摘 要:端粒酶是一种逆转录酶,主要存在于细胞核,其主要功能是维持端粒长度,有助于细胞永生化。现已发现,氧化应激可以改变端粒酶活性,促使端粒酶从细胞核转位到线粒体,因而不能继续维持端粒长度,使细胞端粒缩短。端粒酶线粒体转位的非依赖端粒功能包括改善线粒体功能、减少细胞氧化应激、拮抗细胞凋亡。
关键词:端粒酶;线粒体转位;端粒酶的非依赖端粒功能
中图分类号:R363;Q55    文献标识码:A


    


 

 
Translocation of telomerase to mitochondria
WEN Lei, LING Xian-long*
(Department of Gastroenterology,Xinqiao Hospital, The Third Military Medical University, Chongqing 400038, China)
Abstract:Telomerase is a reverse transcriptase which main exist in nucleus,with the main function of maintaining telomeres,so it contributes to cellular immortality . It has been demonstrated that telomerase activity would be altered upon oxidative stress and excepted from nucleolus to mitochondria as well as telomere shortening. The telomere-independent functions of translocation of telomerase to mitochondria have been related to improved mitochondrial function, decreased oxidative stress and resistaned cell apoptosis.
Key words:Telomerase; translocation to mitochondria; telomere-independent functions of telomerase.
 
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