中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(10): 965-970
胰高血糖素样肽-1及其类似物抗胰岛b细胞凋亡作用及机制的研究进展
高炜炜,王明伟*
(中国科学院上海药物研究所,国家新药筛选中心,上海201203)
摘 要:胰高血糖素样肽-1(glucagon-like peptide-1, GLP-1)及其类似物通过提高增殖、减少凋亡, 从而有效地保护b细胞数量及功能。该文综述了GLP-1及其类似物能够对抗引起b细胞凋亡的多种有害因素——如细胞因子(IL-1b、TNF-a和IFN-g等)、高游离脂肪酸血症、高血糖或低血糖等——进而降低胰岛b细胞的凋亡率,并探讨了相关的作用机制。
关键词:胰高血糖素样肽1;胰岛b细胞;凋亡
中图分类号:R587.1; R977.15    文献标识码:A
 
Effects and mechanisms of glucagon like peptide-1(GLP-1) and its mimetics on the apoptosis of b cells
GAO Wei-wei, WANG Ming-wei*
(The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinses Academy of Sciences, Shanghai 201203, China)
Abstract: Glucagon-like peptide-1(GLP-1) and its mimetic exhibit positive effects on b cell mass by both inceasing proliferation and decreasing apoptosis. Here we review the effects of GLP-1 and its mimetics on apoptosis caused by increased cytokines, glucose inbalance and lipotoxicity shown in both type 1 and type 2 diabetes. Studies in rodents, cell lines and isolated b cells are also analyzed in order to understand the mechanisms associated with the effects.
Key words: glucagon like peptide-1; b-cells; apoptosis
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第2970100 位访问者,欢迎!