中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(9): 906-912
g-分泌酶组件蛋白Nicastrin的研究进展
龙志敏,贺桂琼*
(重庆医科大学神经科学研究中心,人体解剖教研室,重庆 400016)
摘 要:Nicastrin(NCT)是高度糖基化的I型跨膜蛋白,是g-分泌酶复合物的重要组件蛋白之一,广泛分布于人类或鼠的所有细胞类型。它不仅与g-分泌酶的组装和成熟密切相关,其构象及表达变化对g-分泌酶活性和阿尔茨海默病(Alzheimer抯 disease, AD)中b淀粉样蛋白(amyloid protein b, Ab)的产生及降解也起重要调节作用。本文就国际上近几年在NCT的结构、合成、分布、降解及功能等方面的研究进展作一综述。
关键词:Nicastrin;g-分泌酶;b淀粉样蛋白;阿尔茨海默病
 
Progress in the research on Nicastrin, one of essential subunits of g -secretase
LONG Zhi-min, HE Gui-qiong*
(Department of Anatomy, Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China)
Abstract: Nicastrin(NCT), one of the most important components of g-secretase, is a highly glycosylated type I transmembrane glycoprotein. It is expressed in almost all cell types in human and mouse. NCT is not only closely related to the assembly and maturation of g-secretase complex, more importantly, changes of its conformation and expression have a significant effect on the regulation of g-secretase activity, as well as the generation and degradation of amyloid b peptide in Alzheimer抯 disease. This review summarizes the development of structure, synthesis, distribution, degradation and function of NCT in recent years, including that in our laboratory.
Key words: nicastrin; g-secretase; amyloid b peptide; Alzheimer抯 disease
 
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