中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(8): 793-796
多发性骨髓瘤中NF-kB作用机制研究
李 江,胡维新*
(中南大学生物科学与技术学院分子生物研究中心,长沙 410078)
摘  要:多发性骨髓瘤(multiple myeloma, MM)是浆细胞异常增生的恶性肿瘤,其发病机制比较复杂。研究表明,活化NF-kB具有多种生物学功能,它既能调节细胞因子;影响细胞周期,又与血管发生有关,并且与多发性骨髓瘤治疗密切相关。该文就NF-kB在多发性骨髓瘤中的作用机制做一综述。  
关键词:多发性骨髓瘤;NF-kB;细胞因子;细胞周期;治疗
 
The progress of NF-kB mechanism research in multiple myeloma
LI Jiang, HU Wei-xin*
(Institute of Molecular Biology, School of Biological Science and Technology, Central South University, Changsha 410078, China)
Abstract: Multiple myeloma (multiple myeloma, MM) is the abnormal proliferation of malignant plasma cells. Its pathogenesis is complex. The results show that activation of NF-kB has a variety of biological functions, both regulating cell factors, cell cycle, angiogenesis and closely relating with treatment of multiple myeloma. Now, a review of the progress of NF-kB mechanism in multiple myeloma was made in this article.
Key words: multiple myeloma; NF-kB; cytokines; cell cycle; treatment
 
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