中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(8): 778-782
产白介素-17 T细胞在肺部细菌感染中的研究进展
刘嘉琳,李庆云,万欢英*
(上海交通大学医学院附属瑞金医院呼吸科,上海200025)
摘 要:目前产白介素-17(IL-17)T细胞主要包括了产IL-17 CD4+ T细胞即Th17细胞、产IL-17 gd T细胞和产IL-17 CD8+ T细胞等。随着对Th17这一系细胞功能研究的不断深入,发现它们能通过产生IL-17和IL-22等细胞因子参与炎症反应。该文将对产IL-17 T细胞在肺部细菌感染中所起作用的最近研究进展进行综述。
关键词:产白介素-17 T细胞;肺部细菌;感染免疫
 
Reseach progress on IL-17-producing T cells and pulmonary bacterial infection
LIU Jia-lin, LI Qing-yun, WAN Huan-ying*
(Department of Pulmonary, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China)
Abstract: Interleukin-17 is a proinflammatory cytokine that is produced by a variety of cells, including a newly identified subset of activated CD4+ T cells (Th17 cells), gd T cells, CD8+ cells and NKT cells. Th17 cells are thought to be a distinct lineage of Th cells that mainly produce IL-17, IL-22 and other cytokines which are involved in inflammatory response. gd T cells have also been shown to be a potent source of IL-17 and, in some cases, produce more IL-17 than ab T cells. IL-17-producing T cells are important in the host defense against acute pulmonary infection during the early immune response, also have the potential to elicit detrimental responses during chronic infection-related inflammatory conditions. This review will introduce recent research progress on the role of IL-17-producing T cells in the pulmonary bacterial infection.
Key words: IL-17-producing T cells; pulmonary bacterial; infection immunity
 
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