中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(7): 697-702
哺乳动物细胞mRNA剪接调控的分子机制
程 呈,龚秀峰,惠静毅*
中国科学院上海生命科学研究院生物化学与细胞生物学研究所,分子生物学国家重点实验室,上海 200031
摘 要:mRNA的可变剪接是指一个单一的mRNA前体(pre-mRNA)经过不同的剪接加工方式生成多种mRNA变异体(variants)的过程,这些变异体最终可以编码合成具有不同结构和功能的蛋白质。在过去的10多年中,大量数据表明,可变剪接是增加转录组和蛋白质组多样性的重要资源,也是调控哺乳动物细胞基因表达的重要步骤。可变剪接具有高度的组织与发育阶段特异性,并受到外界信号的控制。剪接调控的紊乱与疾病的发生发展密切相关。该文将对哺乳动物细胞mRNA剪接调控的分子机制进行阐述。
关键词:mRNA剪接;剪接调控;可变剪接;信号转导;miRNA;染色质结构
 
Molecular mechanisms of mammalian mRNA splicing regulation
CHENG Cheng, GONG Xiu-feng, HUI Jing-yi*
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally and structurally distinct protein products. Over the past decade, accumulating evidence demonstrated that alternative splicing is a major source of transcriptomic and proteomic complexity and represents an important mechanism that regulates mammalian gene expression. Alternative splicing is often regulated in tissue-and developmental stage-specific manner, or in response to extracellular stimuli. Mis-regulation of alternative splicing causes a wide range of human diseases. This review describes the molecular mechanisms that regulate mammalian alternative splicing.
Key words: mRNA splicing; splicing regulation; alternative splicing; signal transduction; miRNA; chromatin structure
 
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