中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2007, 19(1): 31-
Raf激酶抑制蛋白(RKIP)的生物学功能研究
胡新宙,王 旭,张 伟*
北京师范大学生命科学学院细胞增殖及调控生物学教育部重点实验室,北京 100875
摘 要:Raf激酶抑制蛋白(Raf kinase inhibitor protein,RKIP)属于磷脂酰乙醇胺结合蛋白(phosphatidylethanolamine-binding protein, PEBP)家族,广泛存在于各种生物中,参与了对细胞内多种信号转导通路的调节作用。RKIP可以与Raf-1结合,从而抑制MAPK信号转导通路,并参与了对G蛋白偶联受体信号通路和NF-κB信号通路的调控。RKIP在膜的生物合成、精子发生、神经发育和细胞凋亡等生理过程中发挥重要作用,并参与了老年痴呆症及糖尿病等的病理过程。此外,近年来的研究表明RKIP是一个新的转移抑制因子,可以抑制前列腺癌、人乳腺癌和黑色素瘤细胞的转移,并已成为一个新的前列腺癌诊断标志物。
关键词:Raf激酶抑制蛋白; 信号转导; 前列腺癌; 转移; 细胞凋亡
 
Studies on the biological function of Raf kinase inhibitor protein(RKIP)
HU Xinzhou, WANG Xu, ZHANG Wei*
Ministry of Education Key Laboratory for Cell Proliferation and Regulation Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China
Abstract: Raf kinase inhibitor protein (RKIP) is a member of the phosphatidylethanolamine -binding protein(PEBP) family, which is a widely expressed protein in a variety of different species. It plays a pivotal modulatory role in several intracellular signaling cascades. RKIP binds to Raf-1, and blocks MAPK signaling pathway. Also it has been demonstrated to regulate G-protein-coupled receptor signaling pathway and NF-κB signaling . RKIP plays a critical role in several physiological processes including membrane biosynthesis, spermatogenesis,neural development and apoptosis. It also contributes to pathophysiological processes including Alzheimer{$39}s disease and diabetic nephropathy. Additionally, recent researches show RKIP is a novel metastasis suppressor,which suppresses metastasis in prostate cancer, breast cancer and melanoma cancer. And RKIP becomes a novel prognostic marker in prostate cancer.
key words: RKIP; signal transduction; prostate cancer; metastasis; apoptosis
 
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