中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(4): 362-366
CD4+CD25+调节性T细胞与肿瘤免疫研究进展
张 妍1,迟晓燕2,崔保霞1*
(1 山东大学齐鲁医院妇产科,济南 250012;2 青岛市立医院妇产科,青岛 266011)
摘 要:调节性T细胞(Treg)是一类具有免疫调节功能的细胞群,在机体的免疫耐受中起着关键性作用。它们主要通过细胞-细胞直接接触的方式抑制CD4+ 和CD8+ 效应性T细胞的活化和增殖,来调节获得性免疫系统,阻止自身免疫疾病的发生。Treg中以自然产生的CD4+CD25+ 调节性T细胞(固有Treg细胞)研究最多。在人类,调控效能主要限于CD4+CD25high 亚型。由于Treg独特的生物学功能,它在自身免疫性疾病的发生、移植耐受和肿瘤的发生和转归上越来越受到重视。该文就该类细胞的特点及其与肿瘤关系的研究进展作一综述。
关键词:CD4+CD25+ 调节性T细胞;肿瘤;免疫治疗;化疗
中图分类号:Q28; R73-36  文献标识码:A
 
The research progress of CD4+CD25+ regulatory T cells and the anti-tumor immune
ZHANG Yan1, CHI Xiao-yan2, CUI Bao-xia1*
(1 Department of Obstetrics and Gynecology, Affliated Qilu Hospital, Shandong University, Ji{$39}nan 250012, China;2 Department of Obstetrics and Gynecology, Qingdao Municipal Hospital, Qingdao 266071, China)
Abstract: Treg(Regulatory T cell) is a kind of cells with immune regulation function, which plays a key role in the immunotolerance. They mainly through cells - cells indirect contacting way inhibit the activation and proliferation of CD4+ and CD8+ effect T cells, and to regulate the acquired immune systems and prevent the occurrence of autoimmune diseases. The most studied Treg cell type is the naturally occurring CD4+CD25+ regulatory T cells (natural Treg cells). In humans, regulation efficiency mainly is confined to CD4+CD25high subtype. Due to its unique biological function, Treg in autoimmune disease, transplantation tolerance and cancer{$39}s incidence and prognosis cause more and more attention. In this paper, the characteristics of such cells, and its relationship with tumor research are reviewed.
Key words: CD4+CD25+ Treg; tumor; immunotherapy; chemotherapy
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第2956218 位访问者,欢迎!