中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(4): 321-325
锌转运蛋白8与1型和2型糖尿病的研究进展
奚晓雪, 郭 军
(南京医科大学基础医学实验教学中心, 南京 210029)
摘要:ZnT8(zinc transporter, member 8)是锌离子转运蛋白,主要定位于胰岛b细胞,能将胞浆锌离子转运至胰岛素储存/分泌性囊泡内,其转运功能降低会影响胰岛素合成、储存和分泌,能增加2型糖尿病(T2DM)的发病风险。ZnT8蛋白也可作为抗原引起b细胞自身免疫损伤,诱发1型糖尿病(T1DM)。ZnT8基因多态性是引起其锌离子转运功能和免疫原性变化的重要因素,与糖尿病的发生、发展密切相关。该文综述了ZnT8与T1DM和T2DM的研究进展,提示ZnT8可作为糖尿病防治的新药物靶点。
关键词:锌转运蛋白8;基因多态性;1型糖尿病;2型糖尿病
中国分类号:Q51; R587.1  文献表示码:A
 
Development of the association of ZnT8 with type 1 diabetes and type 2 diabetes
XI Xiao-xue, GUO Jun*
(Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, China)

Abstract: ZnT8 (zinc transporter, member 8) has recently emerged as a major autoantigenic target of type 1 diabetes and the encoding gene also acts as a genetic marker for type 2 diabetes. This transporter, localized in secretion /storage vesicles membrane, facilitates the cellular efflux of zinc from the cytoplasm into intracellular insulin-containing vesicles and provision of zinc for insulin maturation and storage processes. Altered function of ZnT8 in pancreatic b cells of subjects carrying the risk allele might produce zinc imbalance between secretory/storage vesicles and cytoplasm, with subsequent cell death and loss of b cell mass. Therefore, it may serve as a mediator of insulin synthesizes, storage and secretion. The common polymorphism at aa 325 of the protein has been implicated in type 1 diabetes by determining the autoantibody epitope speci?city. The polymorphism of the gene has been suggested for a dual role, which is in modulating anti-ZnT8 self-antibody specificity and conferring genetic susceptibility to type 2 diabetes. In this review, recent progresses of the study in ZnT8 structure, function and the association with type 1 diabetes and type 2 diabetes will be summarized.
Key words: zinc transporter member 8; gene polymorphism type 1; diabetes mellitus;  type 2; dialoetes mellitus


    

 


    

 

 
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