中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(6): 567-574
胰岛淀粉样多肽的研究进展
张 鑫,程 彪,黄 昆*
(华中科技大学同济药学院生物药学系, 武汉430030)
摘 要:由蛋白错误折叠后聚集所产生的淀粉样蛋白沉积是导致老年痴呆症、疯牛病、2型糖尿病等多种疾病的重要因素。由胰岛淀粉样多肽(islet amyloid polypeptide,IAPP)所形成的淀粉样蛋白沉积,具有破坏胰岛b细胞膜结构、诱导b细胞凋亡和损伤b细胞功能的作用,被认为是2型糖尿病的重要致病原因之一。对IAPP的聚集性、聚集体的结构,以及其对b细胞的毒性作用研究,不但有助于明确2型糖尿病的发病机制,而且最新研究也表明抑制IAPP的聚集可有效减少b细胞的凋亡,提高胰岛移植的成功率。因此,IAPP已成为2型糖尿病治疗中一个具有良好前景的靶点。该文对IAPP研究的最新进展进行了简要介绍。
关键词:IAPP; 淀粉样沉积;2型糖尿病
中图分类号:Q593.9; R587.1 文献标识码:A
 
 
Recent progress of islet amyloid polypeptide
ZHANG Xin, CHENG Biao, HUANG Kun*
(Department of Biopharmacy, Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China)
Abstract:Amyloid protein and depositions formed by misfolded proteins have been identified in multiple diseases, including Alzheimer抯 disease mad cow disease, and were considered as an important causative factor of these diseases. In type 2 diabetes, the misfolded islet amyloid polypeptide (IAPP) was identified as the major component of amyloid deposition identified in the autopsy samples of patients?islets of Langerhans. Studies in vivo and in vitro suggested that IAPP can disturb the integrity of b cell membrane, induce b-cell apoptosis and damage b-cell function, and was thus considered as one of the important causative factors of type 2 diabetes. The molecular pathogenesis of type 2 diabetes can be elucidated via studying the mechanisms of IAPP aggregation, multiple IAPP aggregation forms and their respective structures, and its b cell toxicity. On the other hand, inhibition of IAPP aggregation has been proven effectively reducing the b-cell apoptosis and ensuring the success of pancreas transplantation, thus making IAPP a potential therapeutic target of type 2 diabetes. In the present review, the latest progresses on the aggregation of IAPP were summarized.
Key words:IAPP; amyloid; type 2 diabete mellitus
 
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