中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(6): 506-514
记忆性T细胞的形成、维持和功能
刘 昀,吴长有*
(中山大学中山医学院免疫学教研室,广州510080)
摘 要:免疫记忆是指机体在对某一抗原产生特异性识别及应答的同时,记住该抗原,当再次遭遇同一抗原时,能发生快速和强烈的免疫应答。树突状细胞吞噬病原微生物后,通过主要组织相容性复合体分子提呈抗原短肽段,与T细胞相互作用。在T细胞抗原受体信号和共刺激信号的协同作用下,抗原特异性T细胞增殖,收缩,小部分细胞作为记忆细胞长期存活。免疫记忆T细胞在表型特征和功能上都存在多样性。深入研究机体记忆性T细胞的特征,不仅能指导新型疫苗的设计,而且可望帮助治疗疾病。
关键词:T细胞;记忆性;细胞因子
中图分类号:R392.12 文献标识码:A
 
Generation, maintenance and function of memory T cells
LIU Yun, WU Chang-you*
(Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China)
Abstract: Immunological memory is the ability to make a second and more effective immune response to an antigen that encountered previously. Antigen is processed to short peptides and presented by DCs on MHC molecules to initiate the responses of T cells. A TCR signal with co-stimuli leads to clonal expansion of antigen-specific T cells and follows a phase of contraction, in which most short-lived antigen-specific effector T cells die. Some of these cells survive and form long-lived memory cells. Memory cells are heterogeneous in phenotype and function. Understanding the properties of memory T cells will help in the design of vaccines and the immunotherapy for diseases.
Key words: T cells; memory; cytokine
 
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