中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(5): 444-448
CD44+CD24-/low与ALDH1+作为乳腺癌干细胞标志物之异同
韩明利1,吴诚义1*,王艺梦2
1 重庆医科大学附属第一医院内分泌外科,重庆 400016;2重庆医科大学附属第一医院急诊科,重庆 400016
摘  要:越来越多的研究表明,CD44+CD24-/low与ALDH1+都是乳腺癌干细胞标志物。CD44+CD24-/low细胞与ALDH1+细胞具有很多相同的性质,但又有不同的性质和特点。该文主要就CD44+CD24-/low与ALDH1+之间的相同点、两者在乳腺癌干细胞特性方面的差异及其与乳腺癌基因亚型、预后、转移和耐药之间的不同关系等方面作一综述。
关键词:CD44;CD24;ALDH1;乳腺癌;肿瘤干细胞
 
comparison between CD44+CD24-/low and ALDH1+ as the markers of breast cancer stem cells
HAN Ming-li1, WU Cheng-yi1*, WANG Yi-meng2
1 Department of Endocrine Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; 2 Department of Emergency, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Abstract: Breast cancer cells that express CD44 +CD24-/low have been described as cancer stem cells(CSCs). Breast cancer cells expressing elevated levels of aldehyde dehydrogenase 1 (ALDH1) are also described as CSCs with ALDH1+CD44+CD24-/low subpopulation displaying highest tumorigenic potential in NOD/SCID models. CD44 +CD24-/low subpopulation and ALDH1+ subpopulation have many similarities, and also have many different properties and characteristics. Herein, we review and compare the available data reporting utilization of CD44+CD24-/low and ALDH1+ as the markers of breast cancer stem cells.
Key words: CD44; CD24; aldehyde dehydrogenase 1(ALDH1); breast cancer; cancer stem cells (CSCs)
 
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