中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(9): 896-800
基因组水平的插入和缺失变异研究进展
张阁,黄原
(陕西师范大学生命科学学院,西安 710062)
摘 要:插入和缺失(insertion and deletion)是DNA和蛋白质在进化过程中发生的序列长度上的改变,由于缺乏祖先序列的信息,不能肯定其到底是插入事件还是缺失事件,故统称之为增减(indel)。indel是分子水平进化变异的主要来源之一,近年来对这种进化事件的研究已经涵盖了其发生频率、大小、分布模式、序列进化模型及应用等各个方面。该文总结了基因组水平上插入和缺失的研究进展和发生机制;介绍了已经提出的插入和缺失进化模型,包括TKF91、TKF92、“Long Indel”模型和序列环境模型;讨论了插入和缺失作为分子标记在分子进化、基因分型和药物设计等方面的应用。
关键词:插入和缺失;增减;进化模型
 
Advance in genome-wide studies on insertion and deletion variation
ZHANG Ge, HUANG Yuan*
(School of Life Sciences, Shaanxi Normal University, Xi‘an 710062, China)
Abstract: Insertion and deletion are evolutionary changes in sequence length of DNA and protein molecules. They can抰 be identified exactly whether it is an insertion event or a deletion event because of lack of ancestral sequence information, so be jointly called indel. Indel is one of the major sources of evolutionary change at the molecular level. Recent researches about insertion and deletion covered many respects with their frequency, size, distribution pattern, evolutionary model, and application. This review first summarized the results of studies on insertion and deletion at genomic level and their generation mechanisms; then introduced the proposed evolutionary models for indel, including TKF91, TKF92, Long indel model, and sequence context model; finally, the applications of insertion and deletion variation in molecular evolution, genotyping, and drug design were discussed.
Key words: insertion and deletion; indel; evolutionary models
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第2954846 位访问者,欢迎!