中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(5): 401-404
Id-1在恶性肿瘤发生中的作用及其机制
郭斌1, 张成梅2, 刘少华1*
(1 山东大学齐鲁医院 口腔颌面外科,济南 250012;2 山东大学动物实验中心,济南 250012)
摘 要: 分化抑制因子-1(inhibitor of differentiation protein 1, Id-1)是Id转录调节蛋白家族成员之一,属于螺旋-环-螺旋蛋白超家族成员。早期对Id-1的研究认为其主要作用是负向调节正常细胞的分化。近年来研究表明,Id-1在多种肿瘤中过表达并通过多条信号通路促进肿瘤的发生,现就Id-1在肿瘤发生中的作用及其作用机制作一综述。
关键词:分化抑制因子-1;肿瘤发生;机制
 
The roles and mechanisms of Id-1 in tumorigenesis
GUO Bin1, ZHANG Cheng-mei2, LIU Shao-hua1*
1 Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, Jinan 250012, China; 2 Experimental Animal Center, Shandong University, Jinan 250012, China
Abstact: Id-1 (inhibitor of differentiation protein 1) is a member of Id protein family, belongs to the helix-loop-helix proteins superfamily. Early studies have shown that Id-1 mainly acted as a negative regulator of cell differetiation. Recently, Id-1 overexpression has been found in plenty of cancers by promoting tumorigenesis through several  signal pathways. This review will focus on the roles of Id-1 in tumorigenesis and its relative mechanisms.
Key words: inhibitor of differentiation protein 1; tumorigenesis; mechanism
 
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