中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(8): 811-815
抗HCV药物筛选系统研究进展
唐颖蕾,魏大巧,夏雪山
(昆明理工大学生命科学与技术学院,昆明650224)
摘 要:丙型肝炎病毒(Hepatitis C virus, HCV) 感染的持久性引发慢性肝病疾病,并可能发展成为肝硬化和肝癌。目前对HCV的治疗不能达到理想的治疗效果,所以开发新型抗HCV药物迫在眉睫。抗HCV药物筛选的细胞模型,如复制子系统、假病毒系统、细胞培养系统,动物模型,如黑猩猩、uPA-SCID小鼠等,取得了快速的进展,并推动丙型肝炎的研究和抗HCV药物的发现。
关键词:HCV;复制子系统;HCV假病毒;HCV细胞培养系统;黑猩猩;uPA-SCID小鼠
 
Progress in evaluation systems of anti-HCV drugs
TANG Ying-lei, WEI Da-qiao, XIA Xue-shan*
(Faculty of Life Science and Technology, Kunming University of Science and Technology,Kunming 650224, China)
Abstract: Hepatitis C virus (HCV) causes persistent infection and induces serious chronic hepatitis, liver cirrhosis, and ultimately hepatocellular. The current therapyies can not receive satisfactory results, so the development of new anti-HCV drugs is important. The cell models for drug screening, such as replicon system, HCV pseudotype particles, cell culture systems, and the animal model such as  chimpanzees and uPA-SCID mice, have made rapid progress, these progress will propel HCV research and the anti-HCV drug discovery.
Key words:  HCV; replicon system; HCV pseudotype particles; HCV cell culture; chimpanzees; uPA-SCID mice
 
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