中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(2): 169-172
逆转肾小管上皮细胞转分化的Smad信号转导机制
郝艳鹏,张 悦*
(上海中医药大学科技实验中心,上海201203)

摘 要:肾小管上皮细胞转分化(tubular epithelial to menchymal transdifferentiation,EMT)是肾小管间质纤维化的重要病理机制之一。致纤维化细胞因子TGF-b通过几种信号转导途径调节EMT,其中TGF-b/Smads信号通路发挥核心作用。目前研究表明,Smad7、HGF、BMP-7等可通过调控Smads信号通路而逆转EMT,这为肾间质纤维化的防治提供了新的思路。该文主要介绍TGF-b/Smads信号通路在EMT发生的作用,以及Smad7、SnoN、HGF、BMP-7等分子是如何通过抑制Smads信号通路而发挥逆转EMT作用的。
关键词:肾小管上皮细胞;转分化;逆转;信号转导

 
The mechanisms of reversing tubular epithelial myofibroblast transdifferentiation by Smad signal transduction
HAO Yan-peng, ZHANG Yue*
(Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)

Abstract: Tubular epithelial myofibroblast transdifferentiation (EMT) is an important pathomechanism of renal tubulointerstitial fibrosis. Transforming growth factor-b (TGF-b) is the most potent inducer that is capable of initiating and completing the entire EMT course by several signal transduction pathway, among which, TGF-b Smads is the most important one. Studies indicated that Smad7, SnoN, HGF, BMP-7 could reverse EMT by regulating Smads signal pathway, which represents a potential therapeutic approach to renal tubulointerstitial fibrosis. This review tries to interpret the role of TGF-b Smads signal pathway in EMT and the way through which Smad7、SnoN、HGF and BMP-7 reverse EMT by inhibiting Smads signal pathway.
Key words: renal tubular epithelial cell; transdiferentiation;reverse;signal transduction

 
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