中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(2): 139-142
microRNA-155研究进展
李 江,胡维新*
(中南大学生物科学与技术学院分子生物研究中心,长沙 410078)

摘  要:microRNAs(miRNAs)是一类进化上保守的非编码单链小RNA,长19~24个核苷酸,能在转录后降解靶基因mRNA或抑制基因的翻译。microRNA-155(miR-155)具有多种生物学功能,它能影响造血细胞的分化,并在炎症反应、免疫反应中发挥重要作用。大量研究表明,miR-155在多种肿瘤细胞中过表达,推测其与肿瘤的发生发展密切相关。随着研究的深入,miR-155可能成为新的肿瘤标志物及肿瘤基因治疗的新靶点。
关键词:miR-155;造血细胞;炎症反应;免疫反应;肿瘤

 
The progress of microRNA-155 research
LI Jiang, HU Wei-xin*
(Institute of Molecular Biology, School of Biological Science and Technology,Central South University, Changsha 410078, China)

Abstract: microRNAs (miRNAs) are a class of evolutionarily conserved, single-stranded, non-coding RNA molecules consisting of 19~24 nucleotides, which can degrade mRNA of target gene after transcription or suppress gene translation. Recently, miR-155 is proved as a typically multifunctional miRNA that influences the differentiation of hematopoietic cells, and plays an important biological role in inflammatory and immune response. A large number of studies have shown that miR-155 over-expresses in a lot kinds of tumor cells, suggesting it might be involved in the occurrence and development of tumors. We propose that miR-155 is likely to be a novel tumor marker and a potential application of tumor gene therapy.
Key words: miR-155; hematopoietic cells; inflammatory response; immune response; tumor

 
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