中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(2): 129-132
Wnt信号在胚胎干细胞自我更新和分化中的作用
叶守东,谭 理,宋后燕,李 平*
(复旦大学分子医学教育部重点实验室 上海 200032)
摘要:胚胎干细胞分离自胚泡内细胞团,具有无限自我更新和多向分化潜能, 有很大的医学应用前景。Wnt家族是一类分泌型的细胞信号传导蛋白,可以通过复杂的信号传递通路调控胚胎的早期发育,对细胞的分化、增殖及生长具有重要的调节作用。该文就Wnt信号通路调节胚胎干细胞的自我更新和分化作一综述。 
关键词:Wnt信号通路;自我更新;分化   
 
Role of Wnt signalling in the self-renewal and differentiation of embryonic stem cells
YE Shou-dong, TAN Li, SONG Hou-yan, LI Ping*
(The Key Laboratory of Molecular Medicine, Ministry of Education, Shanghai Medical College, Fudan University, Shanghai 20032, China)
Abstract: Embryonic stem cells, derived from the inner cell mass of blastocysts, hold significant potential for clinical therapies because of their distinctive capacity to both self-renew and differentiate into a wide range of specialized cell types. Wnts comprise a large family of secreted glycoproteins that regulate a variety of developmental changes, including cellular proliferation, differentiation and migration. Here, we will review the importance of the Wnt signalling pathway in regulating the self-renewal and differentiation of embryonic stem cells.
Keywords: Wnt; self-renew; differentiation
 
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