中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
《生命科学》入编《中文核心期刊要目总览》2017年版 2018国际生命健康产业(上海)展览会暨高峰论坛 第29卷第7期第941-945页一文撤稿声明
《生命科学》 2018, 30(8): 848-854
BCLAF1研究进展
董长江,丁媛媛,张 峰*
(上海师范大学,上海 200234)
摘 要:BCLAF1 (Bcl2 associated transcription factor 1,又称为BTF) 最初被鉴定为与BCL2 家族的抗凋亡成员相互作用的蛋白质。初步研究表明,该蛋白具有细胞凋亡诱导因子和转录抑制因子的作用。但后续的研究表明,BCLAF1 在更加广泛的过程中起关键作用,这些过程通常不与BCL2 家族成员的作用相关。现总结和概述了BCLAF1 所具有的基本结构域和在细胞中的定位,Bclaf1 在mRNA 的加工成熟、DNA 损伤应答(DNA damage response, DDR)、细胞凋亡、细胞衰老、肺泡发育中的功能,以及BCLAF1 与肿瘤之间的关系,同时对上述过程中可能的分子机制行了阐述和讨论。
 
The research progress of BCLAF1
DONG Chang-Jiang, DING Yuan-Yuan, ZHANG Feng*
(Shanghai Normal University, Shanghai 200234, China)
Abstract: BCLAF1 (Bcl2 associated transcription factor 1, BCLAF1 or BTF) was originally identified as a protein that interacts with anti-apoptotic members of the BCL2 family. Preliminary studies have shown that this protein acts as an apoptosis-inducing factor and a transcriptional repressor. Subsequent studies have shown that BCLAF1 plays a key role in a wide range of processes that are not normally associated with the role of BCL2 family members. This article describes the basic domains of BBCAF1 and its cellular location. The functions of Bclaf1 in mRNA maturation, DNA damage response, cell apoptosis, cell senescence, and alveolar development were summarized, and the relationship between BCLAF1 and tumors was summarized. We also elaborated and discussed possible molecular mechanisms of the above process.
 
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