中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
《生命科学》入编《中文核心期刊要目总览》2017年版 2018国际生命健康产业(上海)展览会暨高峰论坛 第29卷第7期第941-945页一文撤稿声明
《生命科学》 2018, 30(8): 840-847
miR-29家族及其靶基因与恶性肿瘤关系的研究进展
李永懿1, 2,王鲁业1,李 平1,庄子豪1,王兆煊1,陆宇枫1,于永超1,那 嵩1,李传刚3,李墨林4*
(1 大连医科大学临床医学七年制学生,大连 116044;2 美国弗吉尼亚大学学生,夏洛茨维尔VA 22903;3 大连医科大学第二临床学院外科,大连 116023;4 大连医科大学病理生理学教研室,大连 116044)
摘 要:微小RNA-29 (microRNA-29, miR-29) 家族成员包括miR-29a、miR-29b 和miR-29c,是一类与器官纤维化密切相关的小分子RNA。近年研究发现,多种肿瘤组织中存在miR-29s 的表达紊乱。miR-29 家族不但具有抑癌作用,还有促癌作用,其有望成为肿瘤早期诊断、疗效检测或复发监测的重要新靶标。现就miR-29s 及其靶基因在肿瘤细胞增殖、分化、凋亡、侵袭和转移中的作用及其研究进展进行综述。
 
Progress of miR-29 family and its target genes in tumorigenesis
LI Yong-Yi1,2, WANG Lu-Ye1, LI Ping1, ZHUANG Zi-Hao1, WANG Zhao-Xuan1, LU Yu-Feng1, YU Yong-Chao1, NA Song1, LI Chuan-Gang3, LI Mo-Lin4*
(1 Seven-year Program Medical Students, Dalian Medical University, Dalian 116044, China; 2 Student of University of Virginia, Charlottesville, VA 22903, USA; 3 Department of Surgery, The Second Affiliated Hospital, Dalian Medical University, Dalian 116023, China; 4 Department of Pathophysiology, Dalian Medical University, Dalian 116044, China)
Abstract: microRNA-29 (miR-29) family, including miR-29a, miR-29b and miR-29c, is a group of small molecule RNA that is closely related to organ fibrosis. Accumulating studies have demonstrated that aberrant expression of miR-29s could be detected in various tumor tissues. It is thought that miR-29 serves not only as a tumor suppressor but also as a tumor promoter. It was also expected to be served as a potentially valuable tumor marker and a new target for tumor early diagnosis, progression or recurrence surveillance. The progress of miR-29 family and its target genes in tumor proliferation, differentiation, apoptosis, invasion and metastasis will be reviewed in this paper.
 
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