中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2017, 29(6): 600-605
微小RNA-29与恶性肿瘤
郑立敏,龚雪巍,盛德乔*
(三峡大学医学院,肿瘤微环境与免疫治疗湖北省重点实验室,宜昌 443002)
摘 要:miR-29 家族是人类重要的miRNA 分子,在多数恶性肿瘤中扮演抑癌RNA 分子的作用,因而呈现低表达水平,它通过上调抑癌基因表达及调控相关肿瘤信号通路等机制,抑制恶性肿瘤的增殖、分化、侵袭和转移。miR-29 家族不仅能作为恶性肿瘤治疗的靶点,而且在肿瘤的诊断及预后评估方面具有重要价值。
 
MicroRNA-29 and malignant tumor
ZHENG Li-Min, GONG Xue-Wei, SHENG De-Qiao*
(College of Medical Science of China Three Gorges University, Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Yichang 443002, China)
Abstract: Hsa-miR-29 family, an significant miRNA, acts as a tumor suppressor in most malignant tumors. It inhibits tumor proliferation, differentiation, invasion and metastasis by up-regulating the expression levels of tumor suppressor genes and regulating several tumor-related signaling pathways. Hsa-miR-29 family is not only expected to become a new target for malignant tumor therapy, but also has a vital role in clinic diagnosis and prognosis of tumors.
 
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