中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2017, 29(6): 552-556
细胞重编程中的线粒体自噬
张雨薇, 廖 辰, 沈星辉, 黄星卫, 雷 蕾*
(哈尔滨医科大学组织学与胚胎学教研室,哈尔滨 150081)
摘 要:线粒体为细胞生命活动提供主要的能量来源,其线粒体DNA 可以复制传递自身的遗传物质。线粒体能自我更新以替代受损或者衰老的线粒体。线粒体自噬是一种通过自噬方式选择性清除受损或不需要的线粒体的过程。在已分化的细胞和具有多潜能性的早期胚胎或干细胞中,线粒体的形态、分布和代谢方式均不同。现综述了线粒体在早期着床前胚胎、多潜能干细胞和核移植胚胎中的变化,重点讨论了线粒体自噬在早期胚胎发育和体细胞重编程中的作用。
 
Mitophagy in cellular reprogramming
ZHANG Yu-Wei, LIAO Chen, SHEN Xing-Hui, HUANG Xing-Wei, LEI Lei*
(Department of Histology and Embryology, Harbin Medical University, Harbin150081, China)
Abstract: Mitochondria provides main source of energy for cellular life activities. It possesses mitochondrial DNA, which can transfer its own genetic material. Because of mitochondrial self-renewal, the damaged or aged mitochondria need to be eliminated. Mitophagy indeed is the selective degradation of mitochondria by autophagy. The morphology, distribution and metabolism of mitochondria are different in differentiated cells and pluripotent stem cells. In this review, we summarize recent discoveries from mitochondrial studies in preimplantation embryos, induced pluripotent stem cells and somatic cell nuclear transfer embryos, and focus on the role of mitophagy in the early embryonic development and cellular reprogramming.
 
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