中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2017, 29(6): 527-533
亮氨酰-tRNA合成酶在人类疾病治疗中的应用
龙 韬1,2,刘如娟1,2*,王恩多1,3*
(1 中国科学院上海生物化学与细胞生物学研究所,分子细胞科学卓越创新中心,国家分子生物学重点实验室,上海 200031;2 中国科学院大学,北京 100864;3 上海科技大学生命科学与技术学院,上海 201210)
摘 要:氨基酰-tRNA 合成酶是蛋白质合成过程中的关键酶,广泛参与细胞信号转导、免疫、发育以及疾病等复杂的生理过程。而亮氨酰-tRNA 合成酶作为其中的一员,由于对其经典和非经典功能的研究比较透彻,因而受到了药物研发人员的青睐。现综述了亮氨酰-tRNA 合成酶应用于抗病原菌感染和抗肿瘤等方面的研究进展和治疗前景。
 
The application of leucyl-tRNA synthetase in the treatment of human diseases
LONG Tao1,2, LIU Ru-Juan1,2*, WANG En-Duo1,3*
(1 State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China; 2 University of Chinese Academy of Sciences, Beijing 100864, China; 3 School of Life Science and Technology, Shanghai Technology University, Shanghai 201210, China)
Abstract: Aminoacyl-tRNA synthetase plays a key role in protein synthesis. Recently, those enzymes have been reported to involve in many complicated physiological process such as cell signaling, immune response, development and disease. As a member of them, leucyl-tRNA synthetase has been well studied in its canonical and noncanonical functions and gets the favour of drug researchers. This study summarizes the application of leucyltRNA synthetase in anti-infection and anti-tumor.
 
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