中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2017, 29(3): 223-229
ABC转运蛋白结构与转运机制的研究进展
刘艳青,赵永芳*
(中国科学院生物物理研究所,北京 100101)
摘 要:腺苷三磷酸结合盒转运蛋白(ATP-binding cassette transporter, ABC 转运蛋白) 是一类跨膜蛋白,其主要功能是利用ATP 水解产生的能量将底物进行逆浓度梯度运输。这类跨膜转运蛋白具有保守的功能结构域和多样化的生物学功能,广泛分布于原核和真核生物中。近几年的研究结果表明,人类多种疾病,如免疫缺陷、癌症等,都与ABC 转运蛋白病变相关,因此这类转运蛋白结构及转运机制的研究受到广泛关注。现对近几年ABC 转运蛋白结构及其转运机制的研究进展进行讨论。
 
Structure and mechanism of ABC transporter
LIU Yan-Qing, ZHAO Yong-Fang*
(Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China)
Abstract: ATP-binding cassette (ABC) transporters are a large group of membrane proteins that couple transport of a substrate against a chemical gradient and energized directly by the hydrolysis of ATP. These transporters have conserved functional domains and diverse biological functions and are present in both prokaryotes and eukaryotes. In recent years, many studies have shown that human diseases, such as immune deficiency, cancer etc. are related with pathological changes of ABC transporters, so the structures and mechanisms of these transporters have been intensively studied. Here, we will discuss the research progress of ABC transporters' structures and transport mechanisms.
 
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