中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2016, 28(4): 480-485
G-CSF动员造血干细胞机制研究进展
李程程,孟爱民*
(中国医学科学院医学实验动物学研究所,北京 100021)
摘 要:人类粒细胞集落刺激因子(granulocyte colony-stimulating factor, G-CSF) 是临床上广泛应用的细胞因子之一,最早用于治疗中性粒细胞减少症,降低癌症患者化疗后的死亡率。在临床应用中发现,其可以有效地动员骨髓中造血干细胞进入外周血,目前是临床上最常用的造血干细胞动员剂。介绍了G-CSF 的生物学特性,并详细阐述了G-CSF 动员造血干细胞的机制,为临床上G-CSF 提高动员效率、减少副作用,以及为新型造血干细胞动员剂的开发提供理论基础。
 
Research progress on the hematopoietic stem cell mobilization mechanism of G-CSF
LI Cheng-Cheng, MENG Ai-Min*
(Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China)
Abstract: G-CSF has been widely used in clinical, and it is not only used to treat neutropenia, but also used to reduce the mortality of cancer patients after chemotherapy. What’s more, G-CSF is the most widely used hematopoietic stem cell (HSC) mobilization agent at present. The review introduced the biology of G-CSF, and focused on the HSC mobilization mechanism of G-CSF. To explore the exact mechanism is necessary to improve the efficiency of G-CSF mobilization, and to provide a theoretical basis for the development of new hematopoietic stem cell mobilization agents in the future.
 
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