中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
第29卷第7期第941-945页一文撤稿声明 2018基因编辑学术研讨会 关于有网站冒充本刊网站的声明
《生命科学》 2018, 30(2): 157-168
肿瘤细胞“炎化”与NF-κB信号通路的非编码RNA调控
刘湜桦1,2,管洪宇3,黎孟枫1,2*
(1 中山大学中山医学院微生物系,广州 510080;2 热带病防治研究教育部重点实验室
    (中山大学),广州 510080;3 中山大学附属第一医院内分泌内科,广州市 510080)
摘 要:作为转录因子,NF-κB 通过转录调节基因表达参与肿瘤的发生进展。诸多研究表明,几乎在所有肿瘤中都存在肿瘤细胞内NF-κB 信号通路的持续激活。然而,本来在生理状态下受到严格调控的NF-κB 信号通路在肿瘤细胞中如何持续地被激活,其细胞分子生物学机制尚不清楚。现就简要评述非编码RNA(miRNA 和lncRNA) 对肿瘤细胞内NF-κB 炎性通路的调节及其可能的临床转化意义。
 
NcRNA regulation of the NF-κB pathway and intratumor-cell activation of inflammatory signaling
LIU Shi-Hua1,2, GUAN Hong-Yu3, LI Meng-Feng1,2*
(1 Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China; 2 Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou 510080, China; 3 Department of Endocrinology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China)
Abstract: Transcription factor NF-κB plays important roles in the development and progression of malignant tumor through regulating the expression of a wide variety of genes. Constitutive activation of NF-κB has been evidenced in many cancer types. While NF-κB signaling pathway is tightly regulated in physiological settings, quite frequently it is constitutively activated in cancer cells, leading the cancer cells to a status we designate as being “inflamized”.The molecular biology mechanisms underlying the deregulated activation of NF-κB signaling, however, remain unclear. In this review, the regulatory role and possible clinical conversion of non-coding RNA (miRNA and lncRNA) in NF-κB signaling pathway in inflammatory tumor cells will be discussed.
 
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