中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
2018基因编辑学术研讨会      关于有网站冒充本刊网站的声明
《生命科学》 2017, 29(10): 1066-1072
癌变重编程的表观遗传调控机制研究进展
朱平平,范祖森*
(中国科学院生物物理研究所,北京 100101)
摘 要:肿瘤发生和恶化转化过程中导致细胞的异常编程,并由此产生了肿瘤干细胞。肿瘤干细胞具有自我更新和可塑性潜能,是肿瘤起始、转移、耐药和复发的根源。因此,对肿瘤重编程和肿瘤干细胞的研究具有重大科学价值和临床意义。表观遗传调控在肿瘤重编程中发挥重要作用。染色质重塑复合物、组蛋白修饰和非编码RNA 等表观遗传机制都参与了癌变重编程。这些表观遗传调控可以调控肿瘤干细胞的自我更新和分化形成新肿瘤的能力。表观遗传调控癌变重编程、肿瘤干细胞自我更新的调控以及针对肿瘤干细胞表观调控机制的靶向治疗等问题,已成为肿瘤生物学研究的重点。现就染色质重塑复合物、组蛋白修饰和非编码RNA 对癌变重编程和肿瘤干细胞调控的研究进展进行了综述。
 
Progress on epigenetic mechanisms of oncogenic reprogramming
ZHU Ping-Ping, FAN Zu-Sen*
(Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China)
Abstract: Over tumorigenesis and tumor progression, oncogenic reprogramming occurs and consequently forms cancer stem cells (CSCs). With self-renewal and plasticity, CSCs account for tumor initiation, metastasis, drug resistance and relapse. Accordingly, it is of great scientific and clinical significance to investigate CSC biology. Epigenetic regulation mechanisms, including chromatin remodeling complexes, histone modifications and noncoding RNAs, play critical roles in oncogenic reprogramming. Therefore, these epigenetic modulators tightly regulate the self-renewal and differentiation of CSCs, which drive tumor formation and progression. The epigenetic mechanisms of oncogenic reprogramming, regulation of CSC self-renewal, and intervention against epigenetic modulators of CSCs emerge as the frontiers of CSC biology study. In this review, we summarize recent progresses on the epigenetic mechanisms of oncogenic reprogramming and cancer stem cells, including chromatin remodeling,histone modifications, and noncoding RNAs.
 
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