中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
2018基因编辑学术研讨会      关于有网站冒充本刊网站的声明
《生命科学》 2017, 29(10): 946-954
组蛋白变体的功能与识别机制
杨 娜,许瑞明*
(中国科学院生物物理研究所生物大分子国家重点实验室,北京 100101)
摘 要:组蛋白变体(histone variant) 是常规组蛋白的变异体,在染色质的特定位置或特定生物学事件中替换常规组蛋白,调控染色质结构以及相关生物学过程。组蛋白伴侣(histone chaperone) 是指可以结合组蛋白,运送组蛋白参与染色质组装和去组装等重要功能的蛋白质。综述了几种主要组蛋白变体在真核生物染色质高级结构的形成及维持、细胞编程与重编程的表观遗传机制等生命进程中发挥的重要作用,以及这些组蛋白变体与其特征伴侣之间特异识别的分子机制。
 
Histone variants and mechanisms of their recognition
YANG Na, XU Rui-Ming*
(National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China)
Abstract: Histone variants are siblings of canonical histones that have distinct functions. They substitute core histones in nucleosome at special regions of chromatin and during specific biological processes, regulate chromatin structure and associated biological processes. Histone chaperones are a group of proteins that bind to canonical and/or variant histones, assist their traffic and deposition in the process of nucleosome assembly and disassembly. In this review, we discuss recent progresses on the studies of major histone variants for their functions in regulation of chromatin structure and epigenetic reprogramming in eukaryotes, as well as the molecular mechanism governing recognition of major histone variants by their cognate chaperones.
 
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