中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2017, 29(9): 898-907
NLRP3炎症小体介导的炎症相关疾病研究进展
蒋丹露,刘阳阳,孙如愚,陈 晟,王 迪*
(浙江大学基础医学系免疫代谢研究组,杭州 310058)
摘 要:炎症小体在炎症相关疾病的发生发展中发挥重要作用,其中NLRP3 炎症小体能够被多种病原相关分子模式(pathogen-associated molecular patterns, PAMPs) 和损伤相关分子模式(damage-associated molecular patterns, DAMPs) 激活,进而活化caspase-1,释放成熟形式的IL-1β 和IL-18,引起机体的炎症反应,并参与多种疾病的发生发展,包括2 型糖尿病、痛风、动脉粥样硬化、神经退行性疾病、肿瘤、炎症性肠病等。因此,研究NLRP3 炎症小体的作用机制不仅有助于加深对炎症性疾病发生发展的认识,也为寻找此类疾病的潜在治疗靶点提供了新的思路。就NLRP3 炎症小体在炎症相关疾病中的研究进展作一综述。
 
NLRP3 inflammasome and its role in inflammation-related diseases
JIANG Dan-Lu, LIU Yang-Yang, SUN Ru-Yu, CHEN Sheng, WAND Di*
(Research Group of Immune Metabolism, Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China)
Abstract: Inflammasomes play an important role in the initial and progressive process among various inflammation-related diseases. The NLRP3 inflammasome is vital in the innate immune system. It could recognize series of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) and be activated. Activated NLRP3 inflammasome stimulates caspase-1 activation that triggers maturation and secretion of pro-inflammatory cytokines, including interleukin-1β and interleukin-18. A number of recent landmark studies revealed that inflammation-related diseases such as type 2 diabetes, gout, atherosclerosis, neurodegenerative diseases, cancer, inflammatory bowel disease (IBD) are closely related with NLRP3 inflammasome. Thus, study on the NLRP3 inflammasome in inflammation-related diseases not only expands our understanding on these diseases, but also provides a potential therapeutic target for these diseases. Here we review the recent studies on the pathological contributions of NLRP3 inflammasome in various inflammation-related diseases.
 
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