中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2017, 29(9): 816-822
基于肿瘤抗原特异性的T细胞免疫治疗
骆菲菲,王月弟,储以微*
(复旦大学生物治疗研究中心,基础医学院免疫学系,上海 200032)
摘 要:肿瘤抗原特异性T 细胞免疫治疗是基于适应性免疫应答理论的被动免疫疗法,近年来发展迅猛,以TIL、TCR-T、CAR-T 以及BiTE 为代表,已在临床试验中显现出可喜疗效,就其制备原理、安全性及应用前景作一综述。
 
Tumor antigen-specific T cell immunotherapy
LUO Fei-Fei, WANG Yue-Di, CHU Yi-Wei*
(Biotherapy Research Center and Department of Immunology,School of Basic Medical Sciences, Fudan University, Shanghai 200032, China)
Abstract: Tumor antigen-specific T cell immunotherapy is a passive immunotherapy based on the theory of adaptive immune responses, which has developed rapidly in recent years. TIL, TCR-T, CAR-T and BiTE as examples of these immunotherapies have produced impressive results in the clinical trials. In this paper, we review the preparation principle, safety and application prospects of tumor antigen-specific T cell immunotherapy.
 
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