中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2017, 29(2): 202-208
心肌转分化研究进展
李 然, 鲍礼智,沈 明,郑 兴*
(第二军医大学长海医院心血管内科,上海 200433)
摘 要:成人固有心肌细胞受损伤后几乎没有再生能力,是心血管疾病仍然是世界范围内致死率最高的疾病之一的重要原因。通过导入转录因子、microRNA 以及一些小分子等方法的体细胞心肌转分化技术有望解决该医学难题。近年来,成纤维细胞转分化心肌细胞在方法策略、诱导时间及效率上又取得新的重大进展。现对当前该方面体内体外研究进展进行综述。
 
Advances in transdifferentiation of induced cardiomyocytes
LI Ran, BAO Li-Zhi, SHEN Ming, ZHENG Xing*
(Department of Cardiovasology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China)
Abstrac: Cardiovascular disease remains one of the leading causes of mortality worldwide. One of the important reasons is resident cardiomyocytes hardly have the capacity to regenerate in adult heart after injury. Such transdifferentiation, with the use of transcription factors, microRNAs and small molecule delivery to reprogram somatic cells to cardiac cells, has great potential for tackling the compelling medical problem. In recent years, great progress was made in strategy, time consuming and efficiency of transdifferentiation in the generation of cardiomyocytes from fibroblasts. Here, we aim to present a brief overview of the current in vitro and in vivo progress on this topic.
 
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