中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2017, 29(1): 77-89
α-神经毒素与烟碱型乙酰胆碱受体相互作用的研究进展
李江兵1,吴远双1,高雪梅1,王 晨1,张文睿1,孟 汶1,2,孟庆雄1*
(1 昆明理工大学生命科学与技术学院,昆明 650504;2 昆明医科大学第一附属医院疼痛科,昆明 650032)
摘 要:α- 神经毒素(α-neurotoxin, α-NTX) 是眼镜蛇科和海蛇科蛇毒的主要毒性成分之一,属一种非酶类多肽,能以特异的、几乎不可逆的状态与烟碱型乙酰胆碱受体(nicotinic acetylcholine receptor, nAChR) 结合。nAChR 在生物学、病理学、生理学等方面发挥着重要作用,与感觉、认知、疼痛、保护神经元和递质释放等关系密切。神经型nAChR 参与多种脑功能,与多种神经退行性疾病的发生密切相关,如阿尔茨海默病(AD)、帕金森病(PD) 和精神分裂症(Sz) 等。因此,研究α-NTX 与nAChR 的相互作用关系及其作用机制,对深入研究神经活动机制及相关疾病的治疗机理和寻找新型药物等具有重要意义。对α-NTX、nAChR 的结构以及它们之间相互作用的研究进展进行了归纳和评述,对其相互作用位点作了较为详细的介绍。
 
Progress of the interaction between α-neurotoxin and nicotinic acetylcholine receptor
LI Jiang-Bing1, WU Yuan-Shuang1, GAO Xue-Mei1, WANG Chen1, ZHANG Wen-Rui1, MENG Wen1,2, MENG Qing-Xiong1*
(1 Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650504, China; 2 Department of Pain, First Affiliated Hospital of Kunming Medical University , Kunming 650032, China)
Abstract: α-neurotoxin (α-NTX) is the main constituents of Elapidae and Hydrophiidae snake venoms, which is one of the well characterized non-enzymatic proteins. α-NTX shows an antagonistic role for acetylcholine by forming a stable complex after combining with nicotinic acetylcholine receptor (nAChR). The nAChR shows a variety of biological, pathological, and physiological activities, and it participates in sensory, cognitive, pain, and protective effects of neurons and neurohumoral transmission. Neural nAChR participates in many functions of brain. It is closely related to the occurrence of many kinds of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson’s disease (PD), and Schizophrenia (Sz), etc. Hence, it is essential to study the interaction of α-NTX with nAChR, for exploring the mechanism biological functions related to nAChR, the treatment of related diseases and new drugs. In this review, the structure of α-NTX and nAChR, and the interaction of α-NTX and nAChR were summarized.
 
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