中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2016, 28(11): 1328-1336
食管癌基因突变特征
王欣晨1,叶 清2,黄 雷1*
(1 上海交通大学医学院病理生理学教研室,上海 200025;2 上海交通大学医学院仁济医院胸外科,上海 200127)
摘 要:食管癌是世界第八大常见的恶性肿瘤,具有早期症状不典型、预后不良、死亡率高的特点。食管癌的发生发展伴随着一些基因的结构和功能的改变,这些改变与食管癌的易感性、治疗疗效和预后相关,有的可作为早期诊断的标志。现分别从原癌基因、抑癌基因和DNA 修复基因三方面对食管鳞状细胞癌中突变频率较高的基因的突变特征、临床意义以及可能的致病机制进行概述。
 
Gene mutation profile in esophageal cancer
WANG Xin-Chen1, YE Qing2, HUANG Lei1*
(1 School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China;
    2 Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China)
Abstract: Esophageal cancer (EC) is the eighth common cancer all over the world. It’s characterized by lack of typical symptoms in the early stage, poor prognosis and high death. The development and progression of EC is always accompanied with structural and functional alterations of some genes. These typical alterations of genes are related to the tumor susceptibility, prognosis and therapeutic effect, and some of them can become markers for early diagnosis. Here in this article, we are going to review the gene mutation profile in esophageal cancer, including oncogenes, anti-oncogenes and DNA repair genes, and their clinical significance.
 
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