中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2016, 28(9): 1054-1066
中国染色体蛋白质组计划研究进展
彭雪辉1,苏 纳2,李宗桃1*,徐 平1,2*
(1 武汉大学药学院组合生物合成和药物开发教育部重点实验室,武汉 430071;2 北京蛋白质组研究中心,蛋白质组国家大科学设施,军事医学科学院放射与辐射医学研究所蛋白质组学国家重点实验室,北京 102206)
摘 要:人类染色体蛋白质组计划(Chromosome-Centric Human Proteome Project, C-HPP) 是由人类蛋白质组组织(Human Proteome Organization, HUPO) 于2010 年9 月在悉尼召开的第九届国际蛋白质组学大会上正式提出的大型国际合作计划。与生理- 病理驱动的人类蛋白质组计划(Biology/Disease-driven HPP, B/D-HPP)相同,C-HPP 是人类蛋白质组计划(Human Proteome Project, HPP) 的主要工作, 将由中国、美国、澳大利亚、瑞士、意大利等17 个国家的25 个研究团队共同合作,旨在10 年内(2012.09—2022.09) 完成人类24 条染色体和线粒体上蛋白质编码基因产物本身及其修饰产物的检测、验证和确认,注销可能过度注释的编码基因,绘制基因图谱并实现人类基因组的重注释。国内军事医学科学院的贺福初院士和徐平教授、复旦大学的杨芃原教授、华大基因的刘斯奇教授和暨南大学的何庆瑜教授,以及台湾地区的陈玉如教授分别领衔承担了人类第1 号、8 号、20 号和第4 号染色体上蛋白质编码基因的研究任务。综述了我国承担的C-HPP 工作的策略和进展,并提出展望。
 
The research progress of the Chromosome-Centric Human Proteome Project in China
PENG Xue-Hui1, SU Na2, LI Zong-Tao1*, XU Ping1,2*
(1 Key Laboratory of Combinatorial Biosynthesis and Drug Discovery of the Ministry of Education, College of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; 2 Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, National Center for Protein Sciences Beijing, Beijing Proteome Research Center, National Engineering Research Center for Protein Drugs, Beijing 102206, China)
Abstract: The Chromosome-Centric Human Proteome Project (C-HPP) is a major international cooperation project proposed by the Human Proteome Organization (HUPO) at the 9th international conference on proteomics held in Sydney, Australia in September, 2010. Similar to the Biology/Disease-driven Human Proteome Project (B/D-HPP), C-HPP is one component of Human Proteome Project (HPP). Twenty-five research teams from 17 countries including China, America, Australia, Switzerland, Italy, etc, are cooperating to complete the three goals of C-HPP, which are (1) to detect, verify, and validate the protein-coding gene products as well as their single amino acid variants (SAAVs), post-translational modifications (PTMs) and other possible variants on the 24 human chromosomes and mitochondrial DNA; (2) withdraw the over-annotated coding genes; (3) achieve gene mapping and address reannotation of the human genome within 10 years (2012/9-2022/9). HE Fu-Chu and XU Ping from Academy of Military Medical Sciences, YANG Peng-Yuan from Fudan University, LIU Si-Qi from BGI and HE Qing-Yu from Jinan University, and CHEN Yu-Ru from Academia Sinica will respectively lead the work to research the protein-coding genes of human chromosome1, 8, 20 and 4. This paper reviews the strategies and progress of the work Chinese teams undertook in C-HPP, and proposes prospects for our work.
 
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