中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2016, 28(8): 941-948
全化学诱导体细胞重编程和转分化
付艳宾1,2,龙 媛2,谢 欣1,2*
(1 同济大学生命科学与技术学院,上海市信号转导与疾病研究重点实验室,上海 200092;
    2 中国科学院上海药物研究所,中国科学院受体结构与功能重点实验室,国家新药筛选中心,上海 201203)
摘 要:终末分化细胞可以通过重编程和转分化转变为其他类型的细胞,对再生医学领域的研究有重要意义。化学小分子由于结构多样性,及作用剂量、时间的可控性,其在重编程和转分化领域的应用前景广阔。我国科学家在该方向的研究中也取得了许多引人瞩目的成就。对体细胞重编程和转分化的方式、小分子化合物在体细胞重编程研究领域的应用以及全化学诱导体细胞重编程和转分化研究的最新进展,尤其是我国科学家在本领域的进展进行综述。
 
Recent progress in chemical-induced somatic cell reprogramming and trans-differentiation
FU Yan-Bin1,2, LONG Yuan2, XIE Xin1,2*
(1 Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-based Bio-medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; 2 CAS Key Laboratory of Receptor Research,
    the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China)
Abstract: Differentiated somatic cells can be transformed back into pluripotent state or into other types of cells by reprogramming and trans-differentiation, and may provide functional cells for regenerative medicine. Due to their structural versatility and being easy of application in time- and concentration-dependent ways, small molecule compounds are highly useful in inducing somatic cell reprogramming or trans-differentiation. In this review, we summarize the recent progresses in full chemical-mediated reprogramming and trans-differentiation.
 
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