中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2016, 28(6): 630-639
高等植物中的较长非编码RNA:从序列、功能到分子机理
王玉秋,樊 德,邓兴旺,朱丹萌*
(北京大学生命科学学院与现代农学院,北京大学-清华大学生命联合中心,蛋白质与植物基因研究国家重点实验室,北京 100871)
摘 要:随着非编码RNA 预测方法的推陈出新及高通量测序技术的发展,先前由于研究技术所限未能被鉴定注释的较长非编码RNA 逐渐成为研究热点。目前人们在拟南芥、水稻、玉米、苜蓿等高等模式植物中发现大量中等长度及长链非编码RNA,其中一些非编码RNA 在植物生长发育及环境信号响应等关键生物学过程中发挥着重要的调控功能。将着重介绍长度大于50 个核苷酸的非编码RNA 在多种高等植物中的序列、分子特征与功能鉴定的方法与最新进展。同时,对长链非编码RNA 在高等植物中最新报道的作用模式与分子机理进行归纳总结,并展开讨论。
 
Longer noncoding RNAs in higher plants: from the sequence, function to the molecular mechanism
WANG Yu-Qiu, FAN De, DENG Xing-Wang, ZHU Dan-Meng*
(State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, School of Life Sciences and School of Advanced Agriculture Sciences, Peking University, Beijing 100871, China)
Abstract: With the development and innovation of noncoding RNA prediction algorithms and high-throughput sequencing technologies, the research on previously uncharacterized longer noncoding RNAs gradually becomes a frontier in the field. At present, large amounts of intermediate-sized and long noncoding RNAs have been identified in model plants including Arabidopsis, rice, maize, and Medicago etc. And those emerging genes accomplish variety of biological function during development and in response to environmental stimuli. Here, we reviewed the current and fast growing knowledge on the systematic identification and annotation of noncoding RNAs with the size of longer than 50 nt in higher plants. In addition, the recent advances on the regulatory mechanisms of plant long noncoding RNAs will be summarized and discussed.
 
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