中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2016, 28(3): 367-376
HIV-1的隐身术:变异与进化
丁龙飞,何涌泉,陈 健,张晓燕*
(上海市公共卫生临床中心,上海 201508)
摘 要:HIV-1 以其庞大的基因多样性及快速的变异能力,不断地逃逸人类免疫系统的监控,至今为止,尚未研发出有效的疫苗和治愈方法。研究HIV-1 的进化模式及其与人类免疫系统之间的“博弈”,有助于鉴定新的抗病毒治疗靶点、探寻可诱导广谱免疫应答的免疫表位和设计新型有效的艾滋病疫苗。现从HIV-1进化的角度,简述了HIV-1 的起源、分类、流行;讨论了HIV-1 基因多样性产生的原因及其快速的进化模式;分析了HIV-1 变异与中和抗体产生以及特异CTL 作用之间的关联;总结了HIV-1 在抗病毒药物治疗下的进化;最后也概括了HIV-1 适应宿主限制性因子的作用,以期为艾滋病治愈策略及有效疫苗研发提供借鉴。
 
The invisibility of HIV-1: variation and evolution
DING Long-Fei, HE Yong-Quan, CHEN Jian, ZHANG Xiao-Yan*
(Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China)
Abstract: A series of challenges including enormous genetic diversity and rapid evolution, which enable HIV-1 to escape host immune surveillance, has hindered the development of the effectively protective vaccine and a functional cure strategy against HIV-1/AIDS. Exploring the relationship between HIV-1 evolution and human immune responses will help to develop effective HIV-1 vaccines to elicit broaden neutralizing responses and specific cross-reactive CTL responses, which can also help to identify new target for exploring HIV-1/AIDS cure strategy. From an evolutionary perspective, here, we summarized the study progress on origin, classification and epidemic of HIV-1, followed by the genetic diversity and rapid evolution model of HIV-1. In addition, we highlighted the relationship between variability of HIV-1 and the host adaptive immune responses, as well as the variability of HIV-1 under anti-retroviral therapy. The intrinsic host restriction factors were also depicted. We hope that this review will provide clues to design new vaccines and HIV-1/AIDS cure strategies.
 
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