中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2016, 28(2): 137-145
抗原非特异性T细胞对天然免疫炎性反应的调控
陈海荣1,张 超1,张胜源1,王为红1,李舒然1,唐 宏1,2*
(1 中国科学院生物物理研究所感染与免疫重点实验室,北京 100101;2 中国科学院上海巴斯德研究所,上海 200031)
摘 要:天然免疫是抵御微生物入侵的第一道防线,其稳态的建立与维持须受到精确调控。近期研究进展表明,传统意义上抗原特异性免疫细胞——T 细胞,能够以抗原非特异的方式在天然免疫阶段调节炎性反应,并决定了机体对微生物的免疫应答稳态。因此,深入了解T 细胞以及不同T 细胞亚型对天然免疫炎性反应的调控机制,有助于绘制天然免疫新的调控网络,阐述炎性疾病的发病机制,并提供新的治疗策略。
 
Regulation of innate inflammation by antigen non-specific T cells
CHEN Hai-Rong1, ZHANG Chao1, ZHANG Sheng-Yuan1, WANG Wei-Hong1, LI Shu-Ran1, TANG Hong1,2*
(1 Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; 2 Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China)
Abstract: Innate immune response is the first line of defence against invaded pathogens, thus a precise regulation is required to establish and maintain such an innate homeostasis. Emerging evidence has shown that T cells, conventionally functioning in an antigen-specific manner, retains the capability of pathogenic antigen non-specific response, which fundamentally determines the outcome of innate inflammatory response to pathogen infections. Therefore, a better understanding of the mechanisms of how T cells respond and regulate innate inflammation helps to draw a novel regulatory network for innate-immunity, and provide a new dimension to understand the immune pathogenesis and immune intervention against infections.
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第3068737 位访问者,欢迎!