中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2016, 28(1): 124-128
福氏志贺菌O-抗原磷酸乙醇胺修饰研究进展
张凤兰,徐 潇,权亚茹,崔生辉*
(中国食品药品检定研究院,北京 100050)
摘 要:福氏志贺菌是发展中国家引起痢疾的主要致病菌。福氏志贺菌O- 抗原除噬菌体介导的糖基化和( 或)乙酰化外,最近发现一种新的修饰方式磷酸乙醇胺修饰,其机制为由质粒携带的opt 基因编码磷酸乙醇胺转移酶在O- 抗原的鼠李糖II 或( 和) 鼠李糖III 上添加磷酸乙醇胺基团,从而形成血清型Xv、4av 和Yv福氏志贺菌,并表达MASF IV-1 抗原。人工转化携带opt 基因的质粒到无MASF IV-1 抗原表达的不同血清型福氏志贺菌中,转化菌株都能表达MASF IV-1 抗原。在某些血清型福氏志贺菌中,O- 抗原的磷酸乙醇胺修饰与糖基化、乙酰化修饰之间相互作用。现对福氏志贺菌的O- 抗原磷酸乙醇胺修饰机制及其与糖基化、乙酰化修饰间的相互作用进行了综述。
 
Progress of O-antigen phosphoethanolamine modification of Shigella flexneri
ZHANG Feng-Lan, XU Xiao, QUAN Ya-Ru, CUI Sheng-Hui*
(National Institutes for Food and Drug Control, Beijing 100050, China)
Abstract: Shigella flexneri is the major pathogen causing bacillary dysentery in the developing countries. Besides phage-encoded glucosylation and/or O-acetylation, O-antigen of S. flexneri modification with phosphoethanolamine (PEtN) has been identified lately. The plasmid-carried opt gene encodes the phospholethanolamine transferase adding a PEtN on O-antigen rhammose II and/or rhammose III. O-antigen PEtN modification of serotype X, 4a and Y strains convert the hosts into MASF IV-1 positive “variant” Xv, 4av and Yv serotypes respectively. The plasmidcarried opt gene is able to transform all S. flexneri serotypes to make them express MASF IV-1 epitope. Among various serotypes, the PEtN modification of O-antigen may interact with glucosylation and O-acetylation process. Now S. flexneri - O antigen ethanolamine phosphate modification mechanism and its interaction with glycosylation, acetylated modification were reviewed.
 
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