中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2015, 27(10): 1274-1279
MMPs在动脉粥样硬化中的作用及其抑制剂的研究进展
安登坤1,2,梁 浩1,2,宋淑亮1,2,吉爱国1,2,3*
(1 山东大学(威海)海洋学院,威海 264209;2 山东大学(威海)国际生物技术研发中心,威海 264209;3 山东大学药学院,济南 250012)
摘 要:基质金属蛋白酶(MMPs) 是一类肽链内切酶,因其降解细胞外基质(ECM) 和具有金属依赖性而得名。MMPs 能调节单核细胞、巨噬细胞及血管平滑肌细胞(VSMCs) 的黏附、迁移、增殖等,广泛参与动脉粥样硬化(AS) 发展的各个阶段。正常生理情况下,MMPs 与组织金属蛋白酶抑制物(TIMPs) 保持平衡;而在AS 病理情况下,因MMPs/TIMPs 升高而失衡。因此,通过使用特异性抑制剂来抑制某些MMPs 可能为治疗AS 提供新思路。现就MMPs 在AS 中的作用及其抑制剂研究做一综述。
 
Research advances on the role of MMPs and their inhibitors in atherosclerosis
AN Deng-Kun1,2, LIANG Hao1,2, SONG Shu-Liang1,2, JI Ai-Guo1,2,3*
(1 Marine College, Shandong University, Weihai 264209, China; 2 Weihai International Biotechnology Research & Development Centre, Shandong University Weihai 264209, China; 3 School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China)
Abstract: Matrix metalloproteinases (MMPs) are a kind of endopeptidases, named for the metal-dependent characteristics and their ability to degrade the extracellular matrix (ECM). MMPs can adjust adhesion, migration and proliferation capacities of monocytes, macrophages and vascular smooth muscle cells (VSMCs), thus widely participating in the development of atherosclerosis (AS). Under normal physiological conditions, MMPs keep in balance with tissue inhibitors of metalloproteinases (TIMPs). However, the ratio of MMPs to TIMPs can increase in the pathological process of AS. Therefore, specific inhibitors of MMPs may help to provide new ideas for the treatment of AS. This review summarizes research advances on the role of MMPs in atherosclerosis and their
    inhibitors.
 
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