中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2015, 27(7): 928-935
RNA编辑在肿瘤中的研究进展
何安邦1,汪 翔1,张 蒙1*,梅红兵1,2*
(1 安徽医科大学深圳市第二人民医院临床医学院泌尿外科,深圳 518000;2 深圳市第二人民医院泌尿外科,深圳市泌尿生殖系统肿瘤研究重点实验室,深圳 518035)
摘 要:RNA 编辑参与转录后RNA 的调控,已证明与多种肿瘤发生发展相关,现逐渐成为肿瘤领域研究的热点。总结发现RNA 编辑主要通过作用于致瘤相关基因( 如抑癌基因、致癌基因) 转录后RNA 来发挥其相应作用。随着RNA 编辑在肿瘤中的研究深入,可进一步从转录后水平阐明肿瘤发生发展的潜在机制,为肿瘤诊治提供新的思路。
 
Progression of RNA editing in tumor research
HE An-Bang1, WANG Xiang1, ZHANG Meng1*, MEI Hong-Bing1,2*
(1 Urology Department, Shenzhen Second People’s Hospital, Clinical Medicine College, Anhui Medical University,Shenzhen 518000, China; 2 Shenzhen Key Laboratory of Genitourinary Tumor, Department of Urology,Shenzhen Second People’s Hospital, Shenzhen 518035, China)
Abstract: RNA editing is involved in the regulation of post-transcriptional RNA, which is uncovered to be associated with the growth and progression of many cancers, becoming a hot spot of tumor research. It is concluded that RNA editing contributed to the tumorigenesis process mainly by working on the tumor-related genes, such as cancer suppressor genes and oncogenes. As the research of RNA editing in tumor continues, the underlying mechanisms may be further elucidated at the post-transcriptional RNA level, providing a new theoretical basis for tumor diagnosis and therapy.
 
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