中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2015, 27(7): 898-902
ERAP1与强直性脊柱炎关系研究进展
王冠明1*,游玉权2,谢永华1,陈淑增1,林成凤2
(1 泉州医学高等专科学校基础医学部,泉州 362100;2 泉州正骨医院,泉州 362000)
摘 要:HLA-B27 作为强直性脊柱炎(ankylosing spondylitis, AS) 的一个遗传学标志和致病因子为人们所熟知,但随着基因检测技术的发展,更多与AS 相关的基因被发现,包括ERAP1。ERAP1 的主要功能是剪切合适长度的抗原肽,以便MHC-I 类分子提呈,功能异常的ERAP1 与AS 发病相关。在此过程中,ERAP1与HLA-B27 密切配合。ERAP1 分子多态性产生异常抗原肽提呈谱和HLA-B27 分子表达,并通过固有免疫和适应性免疫机制介导AS 发病。现围绕ERAP1 基因与AS 的关系、ERAP1 基因单核苷酸多态性与其功能改变以及ERAP1 参与AS 的免疫机制作一综述。
 
Research progress in the relation between ERAP1 and ankylosing spondylitis
WANG Guan-Ming1*, YOU Yu-Quan2, XIE Yong-Hua1, CHEN Shu-Zeng1, LIN Cheng-Feng2
(1 School of Preclinical Medicine, Quanzhou Medical College, Quanzhou 362100, China; 2 Quanzhou Orthopedics Hospital, Quanzhou 362000, China)
Abstract: It is well known that HLA-B27 is a hereditary marker and susceptibility factor in ankylosing spondylitis (AS). However, further AS-associated genes including ERAP1 were identified with the development of gene detection techniques. The main function of ERAP1 is trimming peptides to optimal length for MHC-I presentation and ERAP1 dysfunction is involved in the pathological mechanism of AS. ERAP1 functions in close concert with HLA-B27 molecules in AS pathogenesis. ERAP1 polymorphisms result in an abnormal peptide-presenting repertoire and HLA-B27 expression, which contribute to AS development by innate and adaptive immune responses. This review focuses on the association of ERAP1 with AS at the gene level, the SNP-dependent alteration in the function of ERAP1 as well as the immunologic mechanism for ERAP1 in AS susceptibility.
 
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