中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2015, 27(5): 640-646
免疫脂质体的研究进展
王贺丽1,韩文琦2,朱 杰3,甄宇红2*,张树彪4*
(1 大连医科大学第一临床学院 (本硕连读),大连 116044;2 大连医科大学药学院,大连 116044;3 大连医科大学附属第二医院,大连 116027;4 大连民族学院生物技术与资源利用国家民委-教育部重点实验室,大连 116600)
摘 要:免疫脂质体作为靶向药物传递体系,具有靶向性、缓释性以及细胞亲和性等独特的优势,成为近年来备受关注的药物载体。免疫脂质体可作为肿瘤化疗药物、放疗药物、基因治疗药物及肿瘤影像诊断剂的载体,用于肿瘤的靶向治疗和检测,在肿瘤临床治疗和诊断中有着广阔的应用前景。综述了免疫脂质体的制备及在肿瘤治疗中的应用进展,以期为免疫脂质体的研究和应用提供参考。
 
Advances in studies of immunoliposomes
WANG He-Li1, HAN Wen-Qi2, ZHU Jie3, ZHEN Yu-Hong2*, ZHANG Shu-Biao4*
(1 The First Clinical College (Accelerated Degree), Dalian Medical University, Dalian 116044, China; 2 College of Pharmacy, Dalian Medical University, Dalian 116044, China; 3 The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China; 4 SEAC-ME Key Laboratory of Biotechnology and Bio-resource Utilization, Dalian Nationalities University, Dalian 116600, China)
Abstract: Immunoliposomes have attracted much attention as targeting drug carriers in recent years, because of their molecular targeting, slow-releasing, cell affinity and other unique advantages. Immunoliposomes can be used in tumor therapy as carriers for chemotherapeutics, radiotherapeutic drugs, gene therapeutic drugs and tumor imaging diagnostic agents, and show a broad prospect of application in clinical treatment and diagnosis. This paper
    reviews the progress in preparation of immunoliposomes and its application in tumor therapy, to provide a reference for the research and application of immunoliposomes.
 
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