中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2015, 27(5): 609-617
动物细胞中活性氧的生成及代谢
耿军伟1,2,于 涵1,2,林 枝1,2,薛 凌1,2,管敏鑫1,2,3*
(1 温州医科大学Attardi线粒体生物医学研究院,温州 325035;2 温州医科大学浙江省医学遗传学重点实验室,温州 325035;3 浙江大学生命科学学院,杭州 310058)
摘 要:我们生活在一个氧气充足的环境中,氧自由基参与的化学反应是需氧生物代谢的一部分。生理低水平的活性氧(reactive oxygen species, ROS) 作为信使分子介导许多生理过程。同时,活性氧积累和氧化损伤参与许多疾病的病理过程。因此,活性氧分子在生理和病理过程中发挥的作用越来越受到人们的关注。现对细胞内可能产生活性氧的部位及其产生机制进行综述,总结概括了细胞内存在的抗氧化系统,列举了目前检测活性氧的方法及其局限性,提出了目前活性氧研究领域亟待解决的问题,最后对临床药理学的靶向抗氧化剂治疗进行展望。
 
Formation and metabolism of reactive oxygen species in cell
GENG Jun-Wei1,2, YU Han1,2, LIN Zhi1,2, XUE Ling1,2, GUAN Min-Xin1,2,3∗
(1 Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical University, Wenzhou 325035, China; 2 Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou 325035, China; 3 College of Life
    Sciences, Zhejiang University, Hangzhou 310058, China)
Abstract: We live in an environment full of oxygen. Oxygen radical species-associated chemical reactions are a part of metabolism in aerobic organisms. Low level of reactive oxygen species acts as signal molecule involving many bioreactions. However, the accumulation of reactive oxygen species (ROS) and oxidative damage are associated with many pathologic processes. The role of ROS in physiological and pathologic process causes more and more attention. This review describes the possible cellular locations and mechanisms of generating ROS in animal cells, summarizes the intracellular antioxidant systems, lists the current detection methods of ROS and its limitation, enumerates some urgent problems in ROS research, and finally, prospects the targeting treatment with
    antioxidants in clinical pharmacology.
 
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