中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2015, 27(5): 574-581
TNF-α在抑郁症中的作用和机制研究
马 柯1,张洪秀2,王广燕1,王 伟1 ,刘宗涛3*
(1 青岛大学医学院,青岛 266073;2 云南省第一人民医院,昆明 650032;3 青岛市第三人民医院,青岛 266003)
摘 要:抑郁症是一种情感精神疾病,临床上以显著而持久的心境低落为主要特征。抑郁症严重危害人们身心健康,降低生活质量,增加社会负担。抑郁的产生原因比较复杂,发病机制存在多种假说。在过去的几十年,虽然对于抑郁症的研究取得了一定的进展,但其确切的病因及病理生理机制目前仍不明确。近期,研究显示,促炎性细胞因子,尤其是肿瘤坏死因子-α (tumor necrosis factor-α, TNF-α) 在抑郁症的发生、发展及临床药理机制中扮演着重要角色。现通过对TNF-α 的生物学特征、在抑郁症发病和抗抑郁治疗中的作用、基因多态性与抑郁症关联性以及未来的应用与展望等进行综述,以期从多方面阐明TNF-α 在抑郁症中的作用。
 
Tumor necrosis factor-α and its role in depression
MA Ke1, ZHANG Hong-Xiu2, WANG Guang-Yan1, WANG Wei1, LIU Zong-Tao3*
(1 Medical College, Qingdao University, Qingdao 266073, China; 2 First People's Hospital of Yunnan Province, Kunming 650031, China; 3 The Third People's Hospital of Qingdao, Qingdao 266003, China)
Abstract: Depression is a mental disorder characterized by a pervasive and persistent low mood in clinic, which is associated with disability and reduced quality of life, as well as a significant social burden. Due to the multifactorial etiology factors of depression, there is a variety of pathogenesis hypothesis. Up to now, however, the pathogensis of depression still remains poorly understood. Most recently, there is a great deal of evidence that the pro-inflammatory cytokines, specifically, tumor necrosis factor-α (TNF-α) play a critical role in the development of depressive disorders and the mechanism of antidepressant treatment. In this paper, we focus on recent progress of the relationship between TNF-α and depressive disorders, and illustrate its biological characteristics, role in the pathophysiology, genetic susceptibility and future applications.
 
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