中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2015, 27(5): 569-573
MicroRNA在阿尔兹海默病中的作用研究
何 祥1,2,王 涛3,杜晓光1,肖世富3,耿美玉1*
(1 中国科学院上海药物研究所,上海 201203;2 南昌大学药学院,南昌 330006;3 上海交通大学医学院附属精神卫生中心,上海 200030)
摘 要:阿尔兹海默病(Alzheimer’s disease, AD) 是一类复杂的神经退行性疾病,也是一类最常见的老年期痴呆。越来越多的研究表明,小RNA(microRNA, miRNA) 在AD 的发生、发展中起着重要的作用。MiRNA是一类单链、长度约22 nt 的非编码小分子,通过靶向mRNA 的非翻译区(untranslated regions, UTR) 来降解mRNA 或抑制其翻译,在神经系统的生长发育、分化及功能执行中扮演着重要角色。现对miRNA 在阿尔兹海默病发病机制中的作用予以综述,重点介绍miRNA 与APP、BACE1、tau、炎症以及神经元凋亡之间的联系。
 
The role of microRNA in Alzheimer's disease
HE Xiang1,2, WANG Tao3, DU Xiao-Guang1, XIAO Shi-Fu3, GENG Mei-Yu1*
(1 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 2 College of Pharmacy, Nanchang University, Nanchang 330006, China; 3 Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China)
Abstract: Alzheimer’s disease (AD) is a complex neurodegenerative disorder and also the most common dementia among the elderly. Accumulating data indicate that microRNAs (miRNAs) are involved in the development of AD. MiRNAs (~22 nt) are non-coding single strand RNA molecules and interact with complementary mRNA sequences in the UTR of genes to result in either translational repression or degradation of the targets. MiRNAs are important in neural development and function. Here, we review current findings regarding the potential contribution of miRNA in the pathogenesis of AD.The relationship between miRNA and APP, BACE1, tau, inflammation and neruo apoptosis are focused on.
 
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