中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2015, 27(5): 564-568
滤泡辅助性T细胞与病毒感染性疾病研究进展
宋 杰,胡云光,刘龙丁*
(中国医学科学院&北京协和医学院医学生物学研究所,云南省重大传染病疫苗研发重点实验室,昆明 650118)
摘 要:滤泡辅助性T 细胞(follicular helper T cells, Tfh) 作为一种新发现的CD4+T 细胞亚群,其主要功能是辅助B 细胞增殖、分化、产生抗体,参与体液免疫应答。由于Tfh 细胞在体液免疫应答中的重要作用,近年来成为研究的热点。现将概述Tfh 细胞的发现、分化过程、相关的调控分子,及其在病毒感染性疾病中的研究进展。
 
Research progress on follicular helper T cells and infectious diseases of virus
SONG Jie, HU Yun-Guang, LIU Long-Ding*
(Yunnan Key Laboratory of Vaccine Research & Development on Severe Infections Disease, Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, Kunming 650118, China)
Abstract: Follicular helper T cells (Tfh), a newly defined CD4+T cell subset that plays an instrumental role in providing help to proliferation and differentiation of B cells for the production of antibodies and protective humoral immunity responses. Owing to the crucial function of Tfh cells, it becomes a research hotspot in recent years. In this review, we highlight advances in our understanding of Tfh cell discovery, differentiation, associated regulation molecules and the studies of virus infection diseases.
 
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