中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2015, 27(4): 471-476
miR-146a/b在动脉粥样硬化疾病中的研究进展
王文俏1#,刘 露1#,许 馨1,任威瑞1,尚 丹2,孙绍光1*
(1 河北医科大学基础医学院生物化学与分子生物学教研室,河北省医学生物技术重点实
    验室,石家庄 050017;2 北京铁路局石家庄卫生防疫站,石家庄 050000)
摘 要:动脉粥样硬化是冠心病等心血管疾病的病理学基础。血管内皮细胞、血管平滑肌细胞和单核/ 巨噬细胞是参与动脉粥样硬化发生发展的重要因素。microRNA 是一类内源性、长约22 个核苷酸的非编码RNA,能够参与调控众多生物学过程,与许多疾病密切相关。miR-146a/b 广泛表达于血管内皮细胞、平滑肌细胞和单核/ 巨噬细胞中,并通过作用于不同靶基因发挥其多样化的生物学功能,参与调控动脉粥样硬化。现就miR-146a/b 与动脉粥样硬化发生发展的关系作一综述。
 
The roles of miR-146a/b in atherosclerosis
WANG Wen-Qiao1#, LIU Lu1#, XU Xin1, REN Wei-Rui1, SHANG Dan2, SUN Shao-Guang1*
(1 Department of Biochemistry and Molecular Biology, Basic Medical College, Hebei Medical University, Hebei Laboratory of Medical Biotechnology, Shijiazhuang 050017, China; 2 Shijiazhuang Health and Epidemic Prevention Station, Beijing Railway Bureau, Shijiazhuang 050000, China)
Abstract: Atherosclerosis, the major cause of cardiovascular disease, is a chronic inflammatory disease. Endothelial cells, vascular smooth muscle cells, and monocytes/macrophages are involved in the initiation and development of
    atherosclerosis. MicroRNAs are a class of endogenous non-coding RNA, containing about 22 nucleotides, which contribute to many biological processes and diseases. MiR-146a/b are widely detected in endothelial cells, vascular smooth muscle cells, and monocytes/macrophages, which participate in diverse biological functions through targeting several different atherosclerosis genes. Here, this review will summarize the relationship between miR-146a/b and atherosclerosis
 
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