中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2015, 27(3): 351-362
蛋白质精氨酸甲基化参与基因转录后调控的研究进展
侯毅枫1,2, 邓 娴1, 陆天聪1,张 勇1,曹晓风1*
(1 中国科学院遗传与发育生物学研究所植物基因组学国家重点实验室,北京 100101; 2 山东农业大学生命科学学院作物生物学国家重点实验室,泰安 271018)
摘 要:蛋白质精氨酸甲基化是真核生物中一种广泛存在并在进化上保守的蛋白质翻译后修饰,由蛋白质精氨酸甲基转移酶(PRMT) 催化完成。动物中的研究表明,PRMT 通过催化多种RNA 结合蛋白的精氨酸甲基化而参与调控细胞多种重要的生命过程,如RNA 代谢、细胞增殖以及信号转导等。概述真核生物中精氨酸甲基化对不同的RNA 结合蛋白的功能调控,并重点阐述该翻译后修饰在转录后加工过程中的重要作用;介绍高等植物拟南芥中蛋白质精氨酸甲基转移酶参与转录后调控的最新研究进展,并对精氨酸甲基化修饰参与调控植物RNA 结合蛋白的功能及今后可能的研究方向进行讨论。
 
Research progress of protein arginine methylation in post-transcriptional regulation
HOU Yi-Feng1,2, DENG Xian1, LU Tian-Cong1, ZHANG Yong1, CAO Xiao-Feng1*
(1 State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; 2 State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai’an 271018, China)
Abstract: Protein arginine methylation, one of the most abundant and evolutionarily conserved post-translational modifications, is catalyzed by the protein arginine methyltransferases (PRMTs). In mammals, by methylating multiple RNA binding proteins (RBPs), PRMTs are involved in various key biological processes, such as RNA processing, cellular proliferation, and signal transduction. Here we overview the regulation by arginine methylation on different RNA binding proteins, and the essential role for arginine methylation in post-transcriptional regulation. In addition, we summarize recent studies on Arabidopsis protein arginine methyltransferases (AtPRMTs). Potential research directions of arginine methylation and RBPs in plants are also discussed.
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第2887397 位访问者,欢迎!